Legal Question in Immigration Law in California

No, it will not affect your ability to re-apply for a "greencard" in the future.

If you give up your U.S. Legal Permanent Residency now, & want to re-apply in the future, then you would have to meet the eligibility requirements & go through the entire process all over again.

Remember that you would then require a U.S. visa in order to enter the country, & any immigration petitions you may have filed on behalf of any relatives will be revoked or denied.

You should also contact an accountant regarding any potential U.S. tax issues.

If you need to depart the U.S. for 6 months to 2 years, I would recommend filing for a re-entry permit instead of giving up your "greencard".